H1-antihistamines for chronic spontaneous urticaria

Paradoxical exacerbation of chronic urticaria by H1-antihistamines and montelukast.

Histamine is the main mediator of urticaria and H1-receptor antagonists represent the treatment of choice in all patients with chronic urticaria. Leukotriene receptor antagonists as montelukast have also been used in patients with chronic urticaria unresponsive to H1-antihistamines alone. We report a patient with chronic urticaria whose disease was paradoxically exacerbated by H1-antihistamines...

Cost-Effectiveness of Omalizumab in Chronic Idiopathic Urticaria Refractory to H1-Antihistamines in Turkey.

PSS3 CoSt-EffECtivEnESS of omalizumab in ChroniC idioPathiC urtiCaria rEfraCtory to h1-antihiStaminES in turkEy Tatar M.1, Sezen S.2, Senturk A.3, Balp M.M.4, Saylan M.2, Keskinaslan A.2 1Hacettepe University, Ankara, Turkey, 2Novartis Pharma, Istanbul, Turkey, 3Polar Polar Health Economics & Policy, Ankara, Turkey, 4Novartis Pharma AG, Basel, Switzerland Objectives: Omalizumab is a humanised a...

Antihistamines in the treatment of chronic urticaria.

Chronic urticaria is highly prevalent in the general population, and while there are multiple treatments for the disorder, the results obtained are not completely satisfactory. The second-generation H1 antihistamines remain the symptomatic treatment option of choice. Depending on the different pharmacokinetics and H1 receptor affinity of each drug substance, different concentrations in skin can...

Antihistamines in chronic urticaria: threat or treat?

Review of H1 antihistamines in the treatment of chronic idiopathic urticaria.

Chronic idiopathic urticaria (CIU) can have a profound effect on patient quality of life (QOL). Ideally, any therapy used to treat CIU should be effective across a wide range of doses without causing unwanted side effects; a wide therapeutic window allows the physician to tailor treatment to the individual. Oral H1 antihistamines are the mainstay of therapy for CIU, but agents within this class...